Replens provides safe, immediate, and long-lasting relief from vaginal itching, burning, and soreness that is associated with vaginal dryness. Vaginal dryness is a common condition resulting from tampon use, childbirth, nursing, medications, stress or menopause. More comfortable applicator! How is Replens Long-Lasting Vaginal Moisturizer different? Replens' patented formula provides soothing moisture that lasts up to three days with every application. With a comfortable applicator, Replens provides relief at the source of discomfort. Other products are lubricants that enhance intimacy, but do not provide long-lasting relief. Whether you experience dryness occasionally or on a regular basis, Replens is the solution for you. Estrogen-free. 14 applications, up to a 42-day supply. One reusable applicator.