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Afrin - Number One Brand in Doctor & Pharmacist Recommendations Fast, powerful congestion relief Maximum Strength Unique Formula with Menthol Afrin Sinus contains a special blend of ingredients which works instantly to cool and soothe your sinuses. Afrin Sinus' special formula also moisturizes dry, irritated nasal passages. It starts to work in seconds providing up to 12 hours of nasal congestion relief without drowsiness. Made in USA